https://fortune.com/2024/10/01/openai-sam-altman-mira-murati...
It's an grab bag of more-or-less common reasons that are present in different relative amounts in different people. In rough order of importance:
1. People are concerned that the leadership is not acting with the best interests of the company in mind, specifically Sam and Greg. See: https://www.reddit.com/r/OpenAI/comments/1804u5y/former_open... and other coverage from the ouster scandal from last winter. This even lead to him walking back from billions of dollars, which is pretty remarkable: https://www.cnbc.com/2024/09/26/openais-sam-altman-tells-emp...
2. People are concerned that the leadership is not acting with the best interests of the public in mind, specifically in regard to the risk of recklessly creating a meaningfully "human-like" AI and giving it control of significant resources. Here's a discussion of how they've moved away from their very pro-public Charter: https://arstechnica.com/information-technology/2024/09/opena... and here's an opinion piece on the risks: https://time.com/6266923/ai-eliezer-yudkowsky-open-letter-no...
3. Other firms are offering huge incentives to OpenAI employees, and engineers are doing what engineers always do: job-hopping to jump a rank or two in the job ladder. From last year, but still relevant IMO: https://techcrunch.com/2023/11/20/openai-ai-talent-poaching-...
4. People are concerned that OpenAI's future is not as bright as it seems given its current (objective) technical dominance, a discussion centering around terms like "moat" and "propriety data" and "open source vs. closed source". Some challenges facing the company include: quite uncertain lawsuits of existential size (https://www.nytimes.com/2023/12/27/business/media/new-york-t...), the fact they're losing $5B/y without a proven path out of that (https://www.datacenterdynamics.com/en/news/openai-training-a...), and, on a meta level, your question itself -- they've lost basically all of their top scientists.
For good general coverage and the quintessential recent example, look for commentary on Mira Murati's exit last week, e.g. https://www.cnn.com/2024/09/25/tech/openai-technology-chief-...